The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Jul. 09, 2019
Flagship Pioneering Innovations V, Inc., Cambridge, MA (US);
Geoffrey A. Von Maltzahn, Somerville, MA (US);
Jacob Rosenblum Rubens, Cambridge, MA (US);
John Miles Milwid, Denver, CO (US);
Michael Travis Mee, Montreal, CA;
Neal Francis Gordon, Brookline, MA (US);
Jagesh Vijaykumar Shah, Lexington, MA (US);
FLAGSHIP PIONEERING INNOVATIONS V, INC., Cambridge, MA (US);
Abstract
The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.