The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Mar. 17, 2025
Applicant:
Denali Therapeutics Inc., South San Francisco, CA (US);
Inventors:
Mihalis S. Kariolis, San Mateo, CA (US);
Melina Lenser, San Francisco, CA (US);
Cathal S. Mahon, San Francisco, CA (US);
Hanh Giai Ngo, San Bruno, CA (US);
Yashas Rajendra, San Mateo, CA (US);
Shrishti Tyagi, Santa Clara, CA (US);
Tianao Yuan, San Mateo, CA (US);
Assignee:
DENALI THERAPEUTICS INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/24 (2006.01); A61P 3/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/2402 (2013.01); A61P 3/00 (2018.01); C12Y 302/0102 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise an acid alpha-glucosidase (GAA) enzyme-Fc fusion polypeptide. Certain embodiments also provide methods of using such proteins to treat Pompe disease.