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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12378536 B1

PDFFull Text
Date of Patent:
Aug. 05, 2025

Filed:

Jun. 08, 2020

Chimeric protein toxins for expression by therapeutic bacteria

Applicant:

David Gordon Bermudes, Woodland Hills, CA (US);

Inventors:

David Gordon Bermudes, Woodland Hils, CA (US);

David Quintero, Northridge, CA (US);

Assignee:

[object Object];

Attorneys:

Hoffberg & Associates

Steven M. Hoffberg

Primary Examiner:

Maria Marvich

Int. Cl.
CPC ...
A61K 35/74 (2015.01); C07K 7/08 (2006.01); C07K 14/005 (2006.01); C07K 14/195 (2006.01); C07K 14/245 (2006.01); C07K 14/415 (2006.01); C12N 9/10 (2006.01); A61K 35/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1077 (2013.01); A61K 35/74 (2013.01); C07K 14/005 (2013.01); C07K 14/245 (2013.01); C07K 14/415 (2013.01); C12Y 204/02036 (2013.01); A61K 2035/11 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/55 (2013.01); C12N 2750/10022 (2013.01); C12N 2750/10033 (2013.01);
Abstract

Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.

Find Patent Forward Citations

Bermudes, David. (2025). Chimeric protein toxins for expression by therapeutic bacteria (U.S. Patent No. 12378536). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12378536

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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