The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 09, 2021
Applicants:
National University of Singapore, Singapore, SG;
Biolamina Ab, Sundyberg, SE;
Inventors:
Karl Tryggvason, Singapore, SG;
Yan Wen Yap, Singapore, SG;
Sun Yi, Sundyberg, SE;
Kristian Tryggvason, Sundyberg, SE;
Assignees:
National University of Singapore, Singapore, SG;
BioLamina AB, Sundyberg, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/077 (2010.01); C12Q 1/6876 (2018.01);
U.S. Cl.
CPC ...
C12N 5/0657 (2013.01); C12Q 1/6876 (2013.01); C12N 2501/115 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/33 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2506/02 (2013.01); C12N 2533/52 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The methods may include differentiating pluripotent stems cells on a substrate including (i) laminin-511 or 521 and (ii) laminin 221. The mature cardiomyocyte cells produced by the method may form a human heart muscle cell line for use in regenerative cardiology.