The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 13, 2022
Applicant:
Thomas Jefferson University, Philadelphia, PA (US);
Inventor:
Mark L. Tykocinski, Merion Station, PA (US);
Assignee:
Thomas Jefferson University, Philadelphia, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 14/47 (2006.01); C07K 14/525 (2006.01); C07K 14/705 (2006.01); C07K 14/78 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); C07K 14/4703 (2013.01); C07K 14/525 (2013.01); C07K 14/70575 (2013.01); C07K 14/78 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01);
Abstract
Provided is a fusion protein comprising a polypeptide component that blocks binding of CD47 to SIRP alpha and a polypeptide that binds to and triggers a TRAIL receptor or Fas. Also provided is a method of treating cancer in a patient comprising administering the fusion protein of the invention to a patient in need of such treatment.