The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Mar. 07, 2020
Memorial Sloan Kettering Cancer Center, New York, NY (US);
The U.s.a, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Tri-institutional Therapeutics Discovery Institute, Inc., New York, NY (US);
Dimitar Nikolov, New York, NY (US);
Nayanendu Saha, New York, NY (US);
Zhongyu Zhu, Frederick, MD (US);
Dimiter Stanchev Dimitrov, Frederick, MD (US);
Dorothea Robev, New York, NY (US);
Thomas Edgeworth White, Norwalk, CT (US);
Abstract
The present invention provides various ADAM17 binding molecules (including antibodies and fragments thereof), compositions comprising such ADAM17 binding molecules, and methods of using such ADAM17 binding molecules and compositions, for example in inhibiting binding of ADAM17 to ADAM17 substrates (such as ErbB ligands), in inhibiting the proliferation of cancer cells, and in treating cancer.