The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 24, 2020
Xuanzhu Biopharmaceutical Co., Ltd., Shijiazhuang, CN;
Beijing Xuanzhu Combio Co., Ltd., Beijing, CN;
Yuntao Song, Palo Alto, CA (US);
Jianhui Zhou, Redwood City, CA (US);
Yi Ding, Milpitas, CA (US);
Ping Hui Szu, Walnut Creek, CA (US);
Chen Dong, Cupertino, CA (US);
XUANZHU BIOPHARMACEUTICAL CO., LTD., Shijiazhuang, CN;
BEIJING XUANZHU COMBIO CO., LTD., Beijing, CN;
Abstract
The present disclosure provides variant CD80 polypeptides that have altered affinity for their cognate binding partners, and immunomodulatory fusion proteins comprising the variant CD80 polypeptides. The present disclosure also provides pharmaceutical compositions comprising such polypeptides and/or proteins and methods for modulating immune responses and/or treatment of cancer, infectious diseases, and/or immunological diseases.