The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Oct. 29, 2019
Applicants:
1globe Biomedical Co., Ltd., Beijing, CN;
1globe Health Institute Llc, Norwood, MA (US);
Inventors:
Chiang J. Li, Cambridge, MA (US);
Shyam Unniraman, Newton, MA (US);
Hannah Bader, Waltham, MA (US);
Alan Lau, Malden, MA (US);
Assignees:
1GLOBE BIOMEDICAL CO., LTD., Beijing, CN;
1GLOBE HEALTH INSTITUTE LLC, Norwood, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/55 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); C07K 16/2827 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/41 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2319/30 (2013.01);
Abstract
Novel compositions and methods relating to or derived from a rationally designed fusion protein composition combines a therapeutic antibody with an IL2 mutant that can simultaneously enhance anti-tumor immunity or derepress tumor-associated immunosuppression along with direct activation of effector cells by IL2 without activating Tare provided. The fusion protein can be used to prevent or therapeutically treat cancer.