The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 26, 2019
Applicant:
Chiesi Farmaceutici Spa, Parma, IT;
Inventor:
Bruno Pietro Imbimbo, Parma, IT;
Assignee:
Chiesi Farmaceutici SpA, Parma, IT;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/48 (2006.01); C07K 1/16 (2006.01); C12N 9/76 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/48 (2013.01); C07K 1/165 (2013.01); C12N 9/6427 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to a process for production of nerve growth factor (NGF) and muteins thereof, in particular muteins of human NGF. The process of the present invention yields nerve growth factor (NGF) and muteins thereof, e.g. from recombinant sources, at high purity. Aspects related to the process of the present invention, such as muteins obtainable thereby, are also described. The respective muteins may be characterized e.g. by improved detectability and/or reduced nociceptive activity, compared to wildtype human NGF.