The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 05, 2025

Filed:

May. 04, 2020
Applicants:

The Regents of the University of California, Oakland, CA (US);

Eth-zurich, Zurich, CH;

Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US);

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Asaf Levy, Concord, CA (US);

Maximilian Mittelviefhaus, Zurich, CH;

Jiamin Miao, Lanzhou, CN;

Kunru Wang, Blacksburg, VA (US);

Bingyu Zhao, Blacksburg, VA (US);

Julia Vorholt-Zambelli, Zurich, CH;

Jeffrey L. Dangl, Chapel Hill, NC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/195 (2006.01); A01N 63/20 (2020.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/06 (2013.01); A01N 63/20 (2020.01); C07K 7/08 (2013.01); C07K 14/195 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention provides for a composition comprising a purified or isolated Hyde1 gene product, or a functional fragment thereof; a modified host cell capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or a functional fragment thereof; a method of treating a disease caused all or in part by a bacterial cell, comprising administering a composition of the present invention to a subject in need thereof; and a method to limit or reduce growth of a pathogenic bacteria in an environment, comprising: introducing a non-pathogenic bacterial capable of expressing a Type VI secretion system (T6SS), Hyde1, and/or Hyde2, or functional fragment thereof, to an environment.


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