Nicotinamide riboside hydrogen malate crystal, and its preparation method and application

Abstract

A nicotinamide riboside hydrogen malate crystal has characteristic peaks respectively at 2θ values of 3.1703±0.2, 6.6434±0.2, 12.5953±0.2, 14.7209±0.2, 15.8502±0.2, 16.5144±0.2, 17.0509±0.2, 17.7053±0.2, 18.6569±0.2, 18.9470±0.2, 19.7757±0.2, 21.4535±0.2, 21.9161±0.2, 22.3721±0.2, 22.9562±0.2, 24.0469±0.2, 24.8641±0.2, 25.2183±0.2, 25.7679±0.2, 27.2584±0.2, 28.5494±0.2, 36.5968±0.2 and 36.8355±0.2. In the preparation of such crystal, DL-malic acid is dissolved in a solvent under stirring, to which a nicotinamide riboside chloride and a base are added for reaction. The reaction mixture is cooled, crystallized at a constant temperature, filtered and dried to give the desired crystal.