The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Jan. 22, 2021
Genentech, Inc., South San Francisco, CA (US);
Jun Liang, South San Francisco, CA (US);
Sushant Malhotra, South San Francisco, CA (US);
Rohan V. Mendonca, South San Francisco, CA (US);
Naomi Rajapaksa, South San Francisco, CA (US);
Michael Siu, South San Francisco, CA (US);
Craig Stivala, South San Francisco, CA (US);
John C. Tellis, South San Francisco, CA (US);
Binqing Wei, South San Francisco, CA (US);
Bryan K. Chan, South San Francisco, CA (US);
Joy Alison Drobnick, South San Francisco, CA (US);
Lewis J. Gazzard, South San Francisco, CA (US);
Timothy Heffron, South San Francisco, CA (US);
Graham Jones, Harlow, GB;
Michael Lainchbury, Harlow, GB;
Andrew Madin, Harlow, GB;
Eileen Mary Seward, Harlow, GB;
Matthew W. Cartwright, Harlow, GB;
Emanuela Gancia, Harlow, GB;
David Favor, Shanghai, CN;
Kin Chiu Fong, Shanghai, CN;
Andrew Good, Shanghai, CN;
Yonghan Hu, Shanghai, CN;
Genentech, Inc., South San Francisco, CA (US);
Abstract
Isoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.