The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 01, 2020
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Barbara Murphy, New York, NY (US);
Bhaskar Das, New York, NY (US);
Chengguo Wei, New York, NY (US);
Li Li, New York, NY (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01); A61P 13/12 (2006.01); C07D 249/12 (2006.01); C07D 277/56 (2006.01); C07D 513/04 (2006.01); C07F 5/02 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); A61P 13/12 (2018.01); C07D 249/12 (2013.01); C07D 277/56 (2013.01); C07D 513/04 (2013.01); C07F 5/025 (2013.01);
Abstract
Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.