logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12378231 B1

PDFFull Text
Date of Patent:
Aug. 05, 2025

Filed:

Feb. 13, 2024

Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof

Applicant:

Apogee Pharmaceuticals, Inc., Burnaby, CA;

Inventors:

Safwat Mohamed Rabea, Richmond, CA;

David Earl Bogucki, Surrey, CA;

Kaiji Hu, Burnaby, CA;

Assignee:

APOGEE PHARMACEUTICALS, INC., Burnaby, CA;

Attorney:

RAPHAEL BELLUM PLLC

Primary Examiner:

Joseph K McKane

Assistant Examiner:

Meghan C Heasley

Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/4192 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/551 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 471/04 (2006.01); C07D 491/056 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61K 31/4192 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/551 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 471/04 (2013.01); C07D 491/056 (2013.01);
Abstract

Disclosed are compounds of Formula I that are useful as Monoacylglycerol lipase (MAGL) inhibitors These compounds may be used in pharmaceutical compositions, formulations, and methods for the treatment of disease states, disorders, and conditions benefited by the inhibition or modulation of MAGL activity, such as, but are not limited to, anxiety and mood disorder, metabolic disorder, a neurodegenerative disorder, mental disorder, brain disorder, pain, inflammatory disorder, cancer, Alzheimer's disease, movement disorders, epilepsy or stroke.

Find Patent Forward Citations

Rabea, Safwat. (2025). Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof (U.S. Patent No. 12378231). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12378231

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…