The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Oct. 16, 2024
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Xiaobin Ge, Changsu, CN;
Henri Mattes, Monfort sur Argens, FR;
Zhicong Shi, Shanghai, CN;
Mei Xia, Shanghai, CN;
Ning Ye, Suzhou, CN;
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); A61K 45/06 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 45/06 (2013.01); C07D 491/048 (2013.01);
Abstract
The present invention relates to novel pyridazin-3-yl phenol compounds of formula (I): wherein R, R, R, Rand Rare defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.