The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Dec. 11, 2019
Applicant:
Heidelberg Pharma Research Gmbh, Ladenburg, DE;
Inventors:
Assignee:
Heidelberg Pharma Research GmbH, Ladenburg, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/20 (2006.01); A61K 47/64 (2017.01); B01J 31/22 (2006.01); B01J 31/24 (2006.01); C07K 7/64 (2006.01);
U.S. Cl.
CPC ...
C07D 209/20 (2013.01); A61K 47/64 (2017.08); B01J 31/2295 (2013.01); B01J 31/2409 (2013.01); C07K 7/64 (2013.01); B01J 2231/645 (2013.01); B01J 2531/822 (2013.01);
Abstract
The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.