The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 05, 2025

Filed:

Mar. 30, 2021
Applicants:

University-industry Cooperation Group of Kyung Hee University, Yongin-si, KR;

Seoul National University R&db Foundation, Seoul, KR;

Inventors:

Young-Sook Son, Seoul, KR;

Su-Min Kim, Seoul, KR;

Noo Li Jeon, Seoul, KR;

Somin Lee, Seoul, KR;

Minhwan Chung, New Haven, CT (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); C12M 1/42 (2006.01); C12M 3/00 (2006.01); C12M 3/06 (2006.01); G01N 33/483 (2006.01);
U.S. Cl.
CPC ...
B01L 3/5027 (2013.01); C12M 21/08 (2013.01); C12M 23/16 (2013.01); C12M 35/08 (2013.01); G01N 33/4833 (2013.01); B01L 2200/027 (2013.01); B01L 2300/0861 (2013.01); G01N 2500/02 (2013.01);
Abstract

Disclosed is a blood-brain barrier vascular network implemented in a microfluidic chip. The blood-brain bather vascular network structure (BBB on a chip) (in vitro blood-brain bather (BBB)-on-a chip) formed in a microfluidic chip manufactured by a present manufacturing method of the in vitro blood-brain barrier (BBB)-on-a chip may reconstruct the blood-brain barrier in a real human body more similarly due to a specific cell configuration, compared to the conventional in vitro blood-brain barrier (BBB)-on-a chip, and thus may be used as a more accurate in vitro blood-brain barrier, and may be used for the development of various cellular therapeutic agents or drugs that work in the treatment of various brain diseases.


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