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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12377149 B1

PDFFull Text
Date of Patent:
Aug. 05, 2025

Filed:

May. 30, 2019

Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3d printing bioink

Applicant:

The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);

Inventors:

Soumya Rahima Benhabbour, Chapel Hill, NC (US);

Panita Maturavongsadit, Chapel Hill, NC (US);

Assignee:

The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);

Attorney:

KDW FIRM PLLC

Primary Examiner:

Sin J Lee

Int. Cl.
CPC ...
A61K 47/38 (2006.01); A61K 9/00 (2006.01); A61K 31/4164 (2006.01); A61K 31/4178 (2006.01); A61K 31/663 (2006.01); A61K 35/12 (2015.01); A61K 38/00 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); B33Y 80/00 (2015.01);
U.S. Cl.
CPC ...
A61K 47/38 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 31/4164 (2013.01); A61K 31/4178 (2013.01); A61K 31/663 (2013.01); A61K 35/12 (2013.01); A61K 47/02 (2013.01); A61K 47/10 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01); A61P 19/08 (2018.01); A61P 19/10 (2018.01); A61P 31/00 (2018.01); A61P 35/00 (2018.01); B33Y 80/00 (2014.12); A61K 2035/124 (2013.01); A61K 38/00 (2013.01);
Abstract

Provided herein are pharmaceutical compositions that include a pharmaceutically active agent, a cellulose nanocrystal or a cellulose nanofiber, a thermogelling biocompatible polymer, and a gelling agent. Such pharmaceutical compositions can be configured as a bioink suitable for 3D printing. Such pharmaceutical compositions are suitable for treating bone disorders, including osteoporosis. Methods of treating Paget's disease, treating or preventing cancer, treating or preventing an infectious disease, and treating or preventing a disorder through regenerative medicine are also provided.

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