The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Jun. 23, 2022
Applicant:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Inventors:
Assignee:
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 47/42 (2017.01); A61K 47/50 (2017.01); A61K 47/68 (2017.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 39/395 (2013.01); A61K 47/42 (2013.01); A61K 47/50 (2017.08); A61K 47/6851 (2017.08); A61K 51/1042 (2013.01); A61P 35/00 (2018.01); C07K 7/00 (2013.01); C07K 14/00 (2013.01); C07K 16/28 (2013.01); C07K 16/32 (2013.01); C07K 19/00 (2013.01); C12N 15/09 (2013.01); C12P 21/00 (2013.01);
Abstract
A multiple antigen-binding molecule fusion molecule containing a multiple antigen-binding molecule (α) having an immune cell antigen-binding region and a cancer antigen-binding region, a cancer tissue-specific protease-cleavable linker (β), and a masking molecule (γ) containing a polypeptide having the amino acid sequence QDGNE (SEQ ID NO: 15), in which the multiple antigen-binding molecule (α) and the masking molecule (γ) are linked via the cancer tissue-specific protease-cleavable linker (β).