The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Oct. 10, 2019
Applicant:
Oxford University Innovation Limited, Oxford, GB;
Inventors:
Assignee:
OXFORD UNIVERSITY INNOVATION LIMITED, Oxford, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 39/015 (2006.01); A61K 39/395 (2006.01); A61P 33/06 (2006.01); C07K 16/20 (2006.01); C12N 15/115 (2010.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/015 (2013.01); A61K 39/39575 (2013.01); A61P 33/06 (2018.01); C07K 16/205 (2013.01); C12N 15/115 (2013.01); A61K 39/00 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/53 (2013.01); C07K 2317/31 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01);
Abstract
There are provided antibodies and combination thereof, and other binding proteins against malarial antigens, as well as said antigens and vectors encoding the antibodies and antigens. The invention also provides the use of such compounds and combinations thereof in the prevention or treatment of malaria. In particular, synergistic combinations of non-neutralising antibodies directed towards an epitope on Reticulocyte-binding protein Homologue 5 (PfRH5) and neutralising antibodies directed towardsmerozoite antigens are provided.