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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12377105 B1

PDFFull Text
Date of Patent:
Aug. 05, 2025

Filed:

May. 17, 2022

Compounds

Applicant:

Tmem16a Limited, Brighton, GB;

Inventors:

Stephen Collingwood, Hayward's Heath, GB;

Clive Mccarthy, Wantage, GB;

Jonathan David Hargrave, Bath, GB;

Duncan Alexander Hay, Wallingford, GB;

Thomas Beauregard Schofield, Oxford, GB;

Sarah Ellam, Didcot, GB;

Craig Stephen Buxton, Didcot, GB;

Matthew Habgood, Abingdon, GB;

Peter Neville Ingram, Abingdon, GB;

Chun Yan Ma, Reading, GB;

Spencer Charles Robert Napier, Didcot, GB;

Abdul Kadar Shaikh, Camberley, GB;

Matthew Raymond Smith, Didcot, GB;

Christopher Charles Stimson, Oxford, GB;

Edward Richard Walker, Didcot, GB;

Assignee:

TMEM16A Limited, Welwyn Garden City, GB;

Attorney:

Robert C. Hall

Primary Examiner:

Joseph K Mckane

Assistant Examiner:

Anna Grace Kuckla

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/167 (2006.01); A61K 31/351 (2006.01); A61K 31/4025 (2006.01); A61K 31/4045 (2006.01); A61K 31/416 (2006.01); A61K 31/44 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/498 (2006.01); A61K 45/06 (2006.01); C07C 233/76 (2006.01); C07D 209/18 (2006.01); C07D 213/81 (2006.01); C07D 231/56 (2006.01); C07D 309/14 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/167 (2013.01); A61K 31/351 (2013.01); A61K 31/4025 (2013.01); A61K 31/4045 (2013.01); A61K 31/416 (2013.01); A61K 31/44 (2013.01); A61K 31/443 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/498 (2013.01); A61K 45/06 (2013.01); C07C 233/76 (2013.01); C07D 209/18 (2013.01); C07D 213/81 (2013.01); C07D 231/56 (2013.01); C07D 309/14 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01);
Abstract

Compounds of general formula (I): wherein R, R, R, R, R, RX, X, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

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