The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2025
Filed:
Apr. 03, 2024
Applicant:
Translate Bio, Inc., Waltham, MA (US);
Inventors:
Frank Derosa, Waltham, MA (US);
Michael Heartlein, Waltham, MA (US);
Shrirang Karve, Waltham, MA (US);
Zarna Patel, Waltham, MA (US);
Assignee:
TRANSLATE BIO, INC., Waltham, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C08G 63/685 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 48/00 (2006.01); C07D 319/12 (2006.01); C08G 63/78 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 9/5153 (2013.01); A61K 9/0019 (2013.01); A61K 9/14 (2013.01); A61K 9/5123 (2013.01); A61K 9/5146 (2013.01); A61K 38/1709 (2013.01); A61K 38/45 (2013.01); C07D 319/12 (2013.01); C08G 63/6852 (2013.01); C08G 63/78 (2013.01); C12Y 201/03003 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01);
Abstract
Disclosed are cationic polymers comprising monomers such as those described in Formula (I), Such polymers can be useful for the preparation of therapeutic compositions (e.g., compositions comprising nucleic acids such as mRNA). Additionally, therapeutic compositions comprising these cationic, biodegradable polymers can have improved properties and reduced toxicity.