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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12377035 B1

PDFFull Text
Date of Patent:
Aug. 05, 2025

Filed:

Jun. 11, 2019

Peptides for inhibiting cholinergic calcitonin gene-related peptide (cgrp) and acetylcholine (ach) release or inhibiting sensitization-mediated by trpv1-mediated excitability in sensory neurons and methods of use thereof

Applicant:

Aziende Chimiche Riunite Angelini Francesco—a.c.r.a.f. S.p.a., Rome, IT;

Inventors:

Francesca Mancini, Nettuno, IT;

Isabel Devesa Giner, Elche, ES;

Antonio Ferrer Montiel, Alicante, ES;

Gregorio Fernandez Ballester, Murcia, ES;

Giorgina Mangano, Rome, IT;

Cristina Bartella, Rome, IT;

Assignee:

AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO—A.C.R.A.F. S.p.A., Rome, IT;

Attorney:

Oblon, McClelland, Maier & Neustadt, L.L.P.

Primary Examiner:

Chang-Yu Wang

Int. Cl.
CPC ...
C07K 4/00 (2006.01); A61K 8/64 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); A61P 27/00 (2006.01); A61P 29/02 (2006.01); A61Q 19/08 (2006.01); C07K 7/00 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
A61K 8/64 (2013.01); A61K 38/04 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61P 25/00 (2018.01); A61P 25/02 (2018.01); A61P 25/04 (2018.01); A61P 27/00 (2018.01); A61P 29/02 (2018.01); A61Q 19/08 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); A61K 38/00 (2013.01);
Abstract

The invention relates to peptides capable of inhibiting neuronal exocytosis and to products comprising such peptides, in particular pharmaceutical and cosmetic products useful for ameliorating skin conditions, disorders and/or diseases mediated by neuronal exocytosis, such as wrinkles, excessive perspiration, pruritus, cutaneous inflammation, dermatitis, atopia, psoriasis, vascular hyperreactivity, rosacea, acne, hair growth, wound healing, calluses, warts, or sensitive skin conditions, such as ulcers and lesions on the skin.

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