The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Nov. 15, 2018
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Towia Aron Libermann, Chestnut Hill, MA (US);
Michelle Lai, Brookline, MA (US);
Nezam Hassan Afdhal, Charlestown, MA (US);
Hasan Huseyin Otu, Lincoln, NE (US);
Simon Thomas Dillon, Rockport, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Abstract
Methods for diagnosing non-alcoholic steatohepatitis (NASH) and NASH with or without advanced liver fibrosis in a subject are provided, such methods including the detection of levels of a variety of biomarkers diagnostic of NASH versus simple steatosis and NASH with advanced liver fibrosis versus NASH without advanced liver fibrosis. The invention also provides methods treating NASH (e.g., NASH with or without advanced liver fibrosis) by administering a biomarker or an agent that modulates a biomarker of NASH or fibrosis. Compositions in the form of kits and panels of reagents for detecting the biomarkers of the invention are also provided.