The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Apr. 30, 2021
Applicant:
University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Inventors:
Mohamed B. Ezzelarab, Pittsburgh, PA (US);
Angus W. Thomson, Pittsburgh, PA (US);
Assignee:
University of Pittsburgh—Of the Commonwealth System, Pittsburgh, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5005 (2013.01); G01N 2333/4703 (2013.01);
Abstract
Pre-existing alloreactive memory T cells are a major barrier to the induction of allograft tolerance in organ transplant recipients. The use of Eomesodermin (Eomes) expression in memory T cells to determine the risk of allograft rejection in a subject is described. Also described is the use of Eomes expression in memory T cells of transplant recipients to modify immunosuppressive therapy.