The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Feb. 25, 2022
Methods of reducing immunogenicity against factor viii in individuals undergoing factor viii therapy
Bioverativ Therapeutics Inc., Waltham, MA (US);
Puget Sound Blood Center, Seattle, WA (US);
Haiyan Jiang, Belmont, MA (US);
Tongyao Liu, Lexington, MA (US);
Sriram Krishnamoorthy, Medford, MA (US);
Neil Josephson, Seattle, WA (US);
Glenn Pierce, Cambridge, MA (US);
BIOVERATIV THERAPEUTICS INC., Waltham, MA (US);
PUGET SOUND BLOOD CENTER, Seattle, WA (US);
Abstract
The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.