The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Jan. 10, 2020
Applicant:
River Stone Biotech Aps, Copenhagen, DK;
Inventors:
Esben Halkjaer Hansen, Copenhagen, DK;
Jens Houghton-Larsen, Copenhagen, DK;
Assignee:
RIVER STONE BIOTECH APS, Copenhagen, DK;
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/02 (2006.01); C12N 15/81 (2006.01); C12P 13/00 (2006.01); C12R 1/865 (2006.01);
U.S. Cl.
CPC ...
C12P 13/001 (2013.01); C12N 9/0071 (2013.01); C12N 15/81 (2013.01); C12R 2001/865 (2021.05); C12Y 114/16002 (2013.01);
Abstract
The present invention relates to a recombinant microbial host cell comprising an operative biosynthetic metabolic pathway capable of producing one or more compounds selected from the group consisting of L-dopa, dopamine, (S)-Norcoclaurine and derivatives thereof; said pathway comprising a heterologous L-tyrosine hydroxylase (TyrH) converting L-Tyrosine into L-dopa capable of increasing the cell production of the Compound compared to a reference L-tyrosine hydroxylase having the sequence set forth in SEQ ID NO: 58.