The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Nov. 13, 2019
Applicant:
University of Hawaii, Honolulu, HI (US);
Inventor:
Iain Seido Macpherson, Honolulu, HI (US);
Assignee:
University of Hawaii, Honolulu, HI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/115 (2010.01); C07H 19/10 (2006.01); C07H 21/04 (2006.01); C12N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C07H 19/10 (2013.01); C07H 21/04 (2013.01); C12N 15/1048 (2013.01); C12N 2310/16 (2013.01); C12N 2310/314 (2013.01); C12N 2310/3513 (2013.01);
Abstract
Compositions and methods for preparing and identifying aptamers and aptamer-protein conjugates are provided. The use of a nucleotide analog functionalized with an amine-reactive cross-linker facilitates covalent cross-linking of the aptamer to a protein, in particular site-specific cross-linking to the Fc domain of an antibody.