The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
May. 13, 2022
Applicants:
Washington University, St. Louis, MO (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Inventors:
Thorold Theunissen, St. Louis, MO (US);
Shafqat Khan, St. Louis, MO (US);
Rudolf Jaenisch, St. Louis, MO (US);
Assignees:
Washington University, St. Louis, MO (US);
Whitehead Institute for Biomedical Research, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/074 (2010.01); C12N 5/0735 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); C12N 5/0606 (2013.01); C12N 2501/999 (2013.01);
Abstract
The present disclosure provides methods and compositions for inducing, maintaining and/or passaging naïve pluripotent stem cell. In some embodiments, the methods are performed in the absence of MEK inhibition which has been shown to result in genomic instability of naïve pluripotent stem cells.