The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 2025

Filed:

Dec. 19, 2023
Applicant:

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Inventors:

Allan B. Dietz, Chatfield, MN (US);

Gaylord Knutson, Rochester, MN (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/19 (2015.01); A61P 17/02 (2006.01); C12N 5/071 (2010.01); C12N 5/0775 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0037 (2013.01); A61K 35/19 (2013.01); A61P 17/02 (2018.01); C12N 5/0068 (2013.01); C12N 5/0662 (2013.01); C12N 5/069 (2013.01); C12N 5/0692 (2013.01); C12N 2500/84 (2013.01); C12N 2501/105 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/165 (2013.01); C12N 2502/115 (2013.01); C12N 2533/50 (2013.01); C12N 2533/90 (2013.01);
Abstract

Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ECs) and mammalian endothelial progenitor cells (EPCs), in particular human ECs (huECs) and human EPCs (huEPCs), such as primary huECs and primary huEPCs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. Also provided are methods for making and using such cell culture media compositions to grow and/or maintain ECs and EPCs, including huECs and huEPCs, as well as cell culture vessels, dishes, plates, and/or flasks pretreated with the cell culture media compositions.


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