The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Jan. 10, 2019
Bioinvent International Ab, Lund, SE;
University of Southampton, Southampton, GB;
Björn Frendéus, Lund, SE;
Ingrid Teige, Lund, SE;
Linda Mårtensson, Bjärred, SE;
Mark Cragg, Southampton, GB;
Stephen Beers, Southampton, GB;
Ali Roghanian, Southampton, GB;
Robert Oldham, Southampton, GB;
BIOVENT INTERNATIONAL AB, Lund, SE;
UNIVERSITY OF SOUTHAMPTON, Southampton, GB;
Abstract
Described is the use of a first antibody molecule that specifically binds FcγRIIb via its Fab region, but lacks Fc region or has reduced binding to Fcγ receptors via its Fc region, for use in combination with a second antibody molecule that specifically binds to a receptor present on an immune cell, wherein the immune cell is an immune cell that suppresses anti-cancer immunity, which second antibody molecule has an Fc region that binds to at least one activating Fcγ receptor, and wherein the binding of the second antibody molecule to the receptor on the immune cell causes depletion and/or deactivation of the immune cell in the treatment of an FcγRIIb-negative cancer in a patient, as well as pharmaceutical compositions and kits comprising these to antibody molecules, and methods of treating cancer using these two antibodies.