The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Apr. 01, 2020
Council of Scientific & Industrial Research, New Delhi, IN;
Rahul Sharad Bhambure, Pune, IN;
Aatir Asad Tungekar, Pune, IN;
Council of Scientific & Industrial Research, New Delhi, IN;
Abstract
The present invention relates to a process for production and recovery of in-vivo refolded recombinant antibody fragment in a soluble form in the cytoplasm of a microbial expression system. More particularly, the present invention relates to a process for production of in-vivo refolded recombinant humanized biosimilar Ranibizumab antibody fragment in a soluble form in the cytoplasm of a microbial expression system. The present process provides an increased yield of the recombinant Ranibizumab accompanied with a reduction in overall manufacturing time for the production of rHu Ranibizumab in its native form to three days.