The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Jul. 15, 2024
Applicant:
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Inventors:
Mikimasa Tanada, Gotemba, JP;
Koji Takano, Kamakura, JP;
Atsushi Matsuo, Kamakura, JP;
Minoru Tamiya, Gotemba, JP;
Aya Chiyoda, Gotemba, JP;
Toshiya Ito, Gotemba, JP;
Takeo Iida, Singapore, SG;
Assignee:
CHUGAI SEIYAKU KABUSHIKI KAISHA, Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07C 271/22 (2006.01); C07C 317/04 (2006.01); C07C 323/09 (2006.01); C07D 205/04 (2006.01); C07D 211/38 (2006.01); C07D 213/55 (2006.01); C07D 213/61 (2006.01); C07D 213/64 (2006.01); C07D 213/65 (2006.01); C07D 295/15 (2006.01); C07D 309/12 (2006.01); C07D 333/28 (2006.01); C07D 409/12 (2006.01); C07F 5/02 (2006.01); C07K 7/64 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); C07C 271/22 (2013.01); C07C 317/04 (2013.01); C07C 323/09 (2013.01); C07D 205/04 (2013.01); C07D 211/38 (2013.01); C07D 213/55 (2013.01); C07D 213/61 (2013.01); C07D 213/64 (2013.01); C07D 213/65 (2013.01); C07D 295/15 (2013.01); C07D 309/12 (2013.01); C07D 333/28 (2013.01); C07D 409/12 (2013.01); C07F 5/025 (2013.01); A61K 38/00 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2603/18 (2017.05);
Abstract
The present inventors found cyclic peptide compounds that interact with Ras, and non-natural amino acids useful for the production of the cyclic peptide compounds. The inventors also found that the cyclic peptide compounds inhibit the binding between Ras and SOS. In addition, the inventors found specific non-natural amino acids contained in the cyclic peptide compounds and methods for production thereof.