The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 2025

Filed:

Feb. 16, 2024
Applicant:

The Governors of the University of Alberta, Edmonton, CA;

Inventors:

James A. Nieman, Sherwood Park, CA;

Jack Jhamandas, Alberta, CA;

Bing Bai, Alberta, CA;

Alexandr Belovodskiy, Alberta, CA;

Wen Fu, Edmonton, CA;

Mostofa Hena, Edmonton, CA;

Michael Houghton, Danville, CA (US);

Appan Srinivas Kandadai, Edmonton, CA;

Ryoichi Kimura, Sanyo-Onoda, JP;

Kamlesh Kumar Sahu, Edmonton, CA;

D. Lorne Tyrrell, Edmonton, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/44 (2006.01); A61K 31/55 (2006.01); A61P 25/28 (2006.01); C07D 243/12 (2006.01); C07D 243/14 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 243/12 (2013.01); A61P 25/28 (2018.01); C07D 241/44 (2013.01); C07D 243/14 (2013.01); C07D 403/12 (2013.01);
Abstract

The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.


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