The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Feb. 20, 2025
Shanghai University of Medicine and Health Sciences, Shanghai, CN;
Xiuhong Lu, Shanghai, CN;
Gang Huang, Shanghai, CN;
Anyang Sun, Shanghai, CN;
Yongsheng Zhang, Shanghai, CN;
Jincheng Wang, Shanghai, CN;
Jinjing He, Shanghai, CN;
SHANGHAI UNIVERSITY OF MEDICINE AND HEALTH SCIENCES, Shanghai, CN;
Abstract
The present invention relates to an isoindol-sulfilimine compound and its preparation and its use as a sigma-2 receptor inhibitor. Compared with the prior art, the isoindol-sulfilimine compound prepared by the present invention can effectively inhibit the sigma-2 receptor activity by binding to the sigma-2 receptor and deformationally regulating the sigma-2 receptor complex, which will lead to the instability of the binding of adjacent Aβ oligomers to the receptor on the synapse, thus leading to the removal of AB oligomers from the synapse. It can be further used for the preparation of new therapeutic drugs for tumor and neurodegenerative diseases.