The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 2025

Filed:

Nov. 11, 2019
Applicant:

Georgia Tech Research Corporation, Atlanta, GA (US);

Inventors:

Ali Fatih Sarioglu, Atlanta, GA (US);

Ruxiu Liu, Atlanta, GA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B29C 33/38 (2006.01); B29C 39/00 (2006.01); B29C 39/42 (2006.01); C23C 14/04 (2006.01); C23C 14/18 (2006.01); G01N 15/10 (2024.01); G01N 15/1404 (2024.01); G03F 7/00 (2006.01); B29K 105/00 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502761 (2013.01); B01L 3/502707 (2013.01); B01L 3/502715 (2013.01); B01L 3/502776 (2013.01); B29C 33/3842 (2013.01); B29C 39/006 (2013.01); B29C 39/42 (2013.01); C23C 14/042 (2013.01); C23C 14/18 (2013.01); G01N 15/1023 (2024.01); G01N 15/1404 (2013.01); G03F 7/0017 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/12 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0636 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0864 (2013.01); B01L 2300/12 (2013.01); B29K 2105/0002 (2013.01); G01N 2015/1019 (2024.01);
Abstract

Embodiments of the microfluidic device may include of an array of microfluidic cell capture chambers, each functionalized with a different antibody to recognize a target antigen, and a network of code-multiplexed Coulter counters placed at strategic nodes across the device to quantify the fraction of cell population captured in each microfluidic chamber. For example, an apparatus may comprise a fluid inlet port divided into a plurality of separate microfluidic paths, each separate microfluidic path configured to transport a plurality of cells, the plurality of separate microfluidic paths, each comprising a plurality of microfluidic cell capture chambers, an outlet port to discharge a merged output of cells from the plurality of microfluidic cell capture chambers, and a plurality of sensors to detect cells passing into or out of a microfluidic cell capture chamber.


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