The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 29, 2025

Filed:

Feb. 07, 2023
Applicants:

University of Maryland, Baltimore, Baltimore, MD (US);

The Board of Regents of the University of Texas System, Austin, TX (US);

Broncus Medical Inc., San Jose, CA (US);

Inventors:

Amit Sawant, Columbia, MD (US);

Robert Timmerman, Westlake, TX (US);

Yulong Yan, Plano, TX (US);

Henky Wibowo, San Jose, CA (US);

Esther Vicente, Baltimore, MD (US);

Arezoo Modiri, Rosedale, MD (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61N 5/10 (2006.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01);
U.S. Cl.
CPC ...
A61N 5/1031 (2013.01); A61N 5/1064 (2013.01); A61N 5/1077 (2013.01); G06T 7/0012 (2013.01); G06T 7/11 (2017.01); A61N 5/1039 (2013.01); A61N 5/1045 (2013.01); A61N 2005/1055 (2013.01); G06T 2207/10076 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/30061 (2013.01);
Abstract

A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.


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