The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Oct. 20, 2022
National Tsing Hua University, Hsinchu, TW;
Praexisio Taiwan Inc., New Taipei, TW;
Lee-Wei Yang, Garland, TX (US);
Kun-Lin Tsai, Hsinchu, TW;
Bang-Chieh Huang, Taipei, TW;
Yi-Yun Cheng, Hsinchu, TW;
Sui-Yuan Chang, Taipei, TW;
NATIONAL TSING HUA UNIVERSITY, Hsinchu, TW;
PRAEXISIO TAIWAN, INC., New Taipei, TW;
Abstract
Provided is a method for treating a SARS-CoV2 3CL-related disease in a subject in need thereof by blocking dimerization of 3C-like main protease (3CL) of the SARS-CoV2, including administering to the subject a first agent which binds to a first binding site of a SARS-CoV2 3CLcomplex and a second agent which binds to a second binding site of the SARS-CoV2 3CLcomplex, wherein the first binding site and the second binding site are functionally different sites in the three-dimensional structure of the SARS-CoV2 3CLcomplex. Also provided is a pharmaceutical combination including the first agent and the second agent for suppressing SARS-CoV2, thereby alleviating COVID-19.