The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 29, 2025
Filed:
Oct. 01, 2021
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Patrick R. Griffin, Jupiter, FL (US);
Mi Ra Chang, Jupiter, FL (US);
Jason Fisherman, Brookline, MA (US);
Peter Suzman, Newton, MA (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/06 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61P 3/00 (2006.01); A61P 3/04 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61P 3/04 (2018.01); A61P 29/00 (2018.01);
Abstract
Disclosed herein are methods and uses of the polypharmacological modulator SR1903 and related compounds for inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and treating diseases and conditions that are related to or mediated by TREM-1, such as inflammatory diseases, autoimmune diseases, metabolic disorders, and castration resistant prostate cancer (CRPC).