The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 22, 2025

Filed:

Feb. 10, 2022
Applicant:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Lian Chye Winston Koh, Stanford, CA (US);

Stephen R. Quake, Stanford, CA (US);

Hei-Mun Christina Fan, Fremont, CA (US);

Wenying Pan, Stanford, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12P 19/34 (2006.01); C12Q 1/6809 (2018.01); C12Q 1/6874 (2018.01); C12Q 1/6876 (2018.01); C12Q 1/6883 (2018.01); G16B 25/10 (2019.01); G16B 40/00 (2019.01); G16B 40/20 (2019.01); G16B 50/00 (2019.01); G16H 10/40 (2018.01); G16H 50/30 (2018.01); G06F 18/2135 (2023.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6874 (2013.01); C12Q 1/6876 (2013.01); G16B 25/10 (2019.02); G16B 40/00 (2019.02); G16B 40/20 (2019.02); G16B 50/00 (2019.02); G16H 10/40 (2018.01); G16H 50/30 (2018.01); C12Q 2600/112 (2013.01); C12Q 2600/158 (2013.01); G06F 18/2135 (2023.01);
Abstract

The invention generally relates to methods for assessing the health of a tissue by characterizing circulating nucleic acids in a biological sample. According to certain embodiments, methods for assessing the health of a tissue include the steps of detecting a sample level of RNA in a biological sample, comparing the sample level of RNA to a reference level of RNA specific to the tissue, determining whether a difference exists between the sample level and the reference level, and characterizing the tissue as abnormal if a difference is detected.


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