The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Apr. 13, 2023
Applicant:
Akouos, Inc., Boston, MA (US);
Inventors:
Emmanuel John Simons, Brookline, MA (US);
Robert Ng, Newton, MA (US);
Michael McKenna, Boston, MA (US);
Assignee:
Akouos, Inc., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 48/00 (2006.01); A61P 27/16 (2006.01); C07K 14/005 (2006.01); C07K 14/55 (2006.01); C07K 16/22 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); A61K 48/0066 (2013.01); A61P 27/16 (2018.01); C07K 14/005 (2013.01); C07K 14/55 (2013.01); C12N 15/86 (2013.01); C07K 2317/24 (2013.01); C07K 2317/55 (2013.01); C07K 2317/76 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14152 (2013.01);
Abstract
The present disclosure provides a construct comprising a coding sequence operably linked to a promoter, wherein the coding sequence encodes a vascular endothelial growth factor (VEGF) binding agent or a portion thereof. In some embodiments, a construct is an AAV construct. In some embodiments, an AAV construct is a part of an AAV particle. Compositions comprising constructs and AAV particles described herein can be useful in treating hearing loss, for example, hearing loss associated with vestibular schwannoma.