The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Oct. 18, 2019
University of Maryland, College Park, College Park, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
International Aids Vaccine Initiative, New York, NY (US);
Yuxing Li, Boyds, MD (US);
James Steinhardt, Westminster, MD (US);
Javier Guenaga, San Diego, CA (US);
John R. Mascola, Rockville, MD (US);
Tae-Wook Chun, North Bethesda, MD (US);
Susan Moir, Washington, DC (US);
Chi-I Chiang, Rockville, MD (US);
University of Maryland, College Park, College Park, MD (US);
University of Maryland, Baltimore, Baltimore, MD (US);
The United States of America, as Represented by the Secretary, Department of Health and Human Servives, Bethesda, MD (US);
International AIDS Vaccine Initiative, New York, NY (US);
Abstract
The present invention provides a multispecific anti-HIV antibody that binds to multiple epitopes on HIV envelope protein, wherein the antibody comprises: i. an amino acid sequence that binds to a V1/V2 apex glycan epitope; ii. an amino acid sequence that binds to a V3-base glycan region epitope; iii. an amino acid sequence that binds to a CD4 binding site (CD4bs) epitope; iv. an amino acid sequence that binds to a gp120/gp41 interface epitope; and v. an amino acid sequence that binds to a membrane proximal external region (MPER) epitope.