logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12365714 B1

PDFFull Text
Date of Patent:
Jul. 22, 2025

Filed:

Mar. 05, 2019

Methods and compositions for treating cancer with ecm-affinity peptides linked to cytokines

Applicant:

The University of Chicago, Chicago, IL (US);

Inventors:

Jeffrey A. Hubbell, Chicago, IL (US);

Jun Ishihara, Chicago, IL (US);

Ako Ishihara, Chicago, IL (US);

Koichi Sasaki, Chicago, IL (US);

Melody Swartz, Chicago, IL (US);

Aslan Mansurov, Chicago, IL (US);

Assignee:

The University of Chicago, Chicago, IL (US);

Attorney:

Norton Rose Fulbright US LLP

Primary Examiner:

Michael D Pak

Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 14/55 (2006.01); C07K 14/755 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); A61K 9/0019 (2013.01); A61K 38/2013 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/755 (2013.01); C07K 2319/00 (2013.01);
Abstract

The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with a cytokine that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.

Find Patent Forward Citations

Quick Actions:

Hubbell, Jeffrey. (2025). Methods and compositions for treating cancer with ecm-affinity peptides linked to cytokines (U.S. Patent No. 12365714). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12365714

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…