The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Mar. 08, 2021
Suzhou Ark Biopharmaceutical Co., Ltd., Suzhou, CN;
Cheng Peng, Suzhou, CN;
Yang Zhou, Suzhou, CN;
Yanfei Wang, Suzhou, CN;
Mengfei Qian, Suzhou, CN;
Zhaoxiong Cai, Suzhou, CN;
Gang Zou, Suzhou, CN;
Haiqing Yuan, Suzhou, CN;
Zhen Jim Wu, Suzhou, CN;
SUZHOU ARK BIOPHARMACEUTICAL CO., LTD., Suzhou, CN;
Abstract
The present disclosure provides an elastase inhibitor prodrug and use thereof, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer or solvate thereof, prodrugs or isotopically labeled compound. Compared with the compound 52 (control example) in WO 2018/175173 A1, the compound disclosed herein has the advantages of high pulmonary exposure and long half-life. The prodrugs of the present disclosure significantly increase the concentration and residence time of the active compound (control example) in the lungs with significant improvements in pharmacokinetics in vivo compared to the control example.