The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Jul. 18, 2019
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Nathanael S. Gray, Boston, MA (US);
Tinghu Zhang, Brookline, MA (US);
Eric Fischer, Chestnut Hill, MA (US);
Guangyan Du, Jamaica Plain, MA (US);
Nozhat Safaee, Brookline, MA (US);
Nathaniel Henning, Brookline, MA (US);
Katherine Donovan, Boston, MA (US);
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 419/14 (2006.01); C07D 403/12 (2006.01); C07D 495/14 (2006.01);
U.S. Cl.
CPC ...
C07D 419/14 (2013.01); C07D 403/12 (2013.01); C07D 495/14 (2013.01);
Abstract
Disclosed are bifunctional compounds, pharmaceutical compositions containing them, and methods of making and using them to treat diseases and disorders characterized by aberrant protein activity wherein the protein is targeted for degradation by KEAP1 and the Cul3-based E3-ubiquitin ligase complex.