The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Feb. 07, 2020
Serum Institute of India Pvt Ltd., Pune Maharashtra, IN;
Rajeev Mhalasakant Dhere, Pune Maharashtra, IN;
Leena Ravindra Yeolekar, Pune Maharashtra, IN;
Milan Shomenath Ganguly, Pune Maharashtra, IN;
Parikshit Dharampal Tyagi, Pune Maharashtra, IN;
Umesh Gorakh Sagar, Pune Maharashtra, IN;
Swapnil Prabhakar Narale, Pune Maharashtra, IN;
Yashodhan Dilip Anaspure, Pune Maharashtra, IN;
Sham Ramdas Tupe, Pune Maharashtra, IN;
Serum Institute of India Private Limited, Pune Maharashtra, IN;
Abstract
The present disclosure provides compositions and methods for manufacturing and obtaining a live attenuated Influenza vaccine (LAIV) composition that can be delivered intranasally to provide protection against influenza virus infection. Said LAIV strains are based on cold adapted, temperature sensitive and attenuated phenotypes of master donor viruses (MDVs) containing the surface glycoprotein genes of the wild type pandemic or seasonal influenza strains. Also, said LAIV strains are further adapted to grow in MDCK cells (Madin Darby canine kidney cells). The use of eggs is avoided in large scale vaccine manufacturing. The purification process is devoid of chromatography steps. The said LAIV composition includes one or more live attenuated influenza vaccine virus and is devoid of polymers and surfactants.