The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2025
Filed:
Jan. 27, 2021
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7105 (2006.01); A61P 25/14 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2018.01);
U.S. Cl.
CPC ...
A61K 31/7105 (2013.01); A61P 25/14 (2018.01); C07K 14/47 (2013.01); C07K 14/4705 (2013.01); C07K 16/18 (2013.01); C12N 15/1138 (2013.01); C07K 2317/34 (2013.01);
Abstract
Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.