The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Apr. 21, 2022
Structura Biotechnology Inc., Toronto, CA;
Ali Punjani, Toronto, CA;
David Fleet, Toronto, CA;
STRUCTURA BIOTECHNOLOGY INC., Toronto, CA;
Abstract
Provided are systems and methods for determining 3D structure and 3D motion of a protein molecule from 2D or 3D particle observation images. The method includes: initializing pose parameters and unknown model parameters; performing image formation which includes: generating one or more 3D deformation fields by inputting a latent coordinate vector into the one or more flow generators; performing a convection and projection operation; and performing CTF corruption; fitting the unknown model parameters to the experimental images by gradient-based optimization of an objective function; latent variable search for a given experimental image which includes: performing the image formation one or more times to generate simulated images; and selecting one or more latent coordinate vectors based on similarity; and updating the at least one of the unknown model parameters which includes: generating simulated images; and evaluating the objective function; computing the gradient of the objective function.