The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Oct. 29, 2021
Zhejiang University, Hangzhou, CN;
Cuifang Kuang, Hangzhou, CN;
Xu Liu, Hangzhou, CN;
Wanjie Dong, Hangzhou, CN;
Shaocong Liu, Hangzhou, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
Abstract
Disclosed is a phase-modulated fluorescence differential microscopic imaging device based on electro-optical modulation technology, including an illumination system for generating an excitation beam, a detection system for collecting a fluorescent signal emitted by a sample, and a computer for controlling and signal processing. The illumination system includes the following components that are sequentially arranged: a laser, emitting a laser beam; an electro-optical modulation module, configured to control a rapid conversion of the laser beam between a right-handed circularly polarized light and a left-handed circularly polarized light; and a phase modulation device, configured to modulate a circularly polarized light to form a solid light spot and a hollow light spot for illuminating the sample and exciting fluorescence. Also disclosed is a phase-modulated fluorescence differential microscopic imaging method based on the electro-optical modulation technology, which realizes a rapid conversion of a solid light spot and a hollow light spot, and improves the imaging speed of the fluorescence differential microscopic imaging system to a large extent.