The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Jan. 26, 2023
Applicant:
Glaxosmithkline Intellectual Property Development Limited, Stevenage, GB;
Inventors:
Taraka Sai Pavan Grandhi, Collegeville, PA (US);
Aaron Tien-Hsin Cheng, Collegeville, PA (US);
Jason Elliot Ekert, Collegeville, PA (US);
Terrence Taelim Roh, Collegeville, PA (US);
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); B01L 3/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5029 (2013.01); B01L 3/5027 (2013.01); G01N 33/505 (2013.01); B01L 2200/0694 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/069 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0864 (2013.01);
Abstract
An assay system permits study of cell migration through tissue-relevant extracellular matrices under a chemokine gradient within a modular assay platform. Activated CD3+ T-cells were detected, quantified, and studied as they migrated towards chemokines (CXCL10 and CXCL12) and chemokine mimetics (CXCR3 agonist) using the assay system. Discovery of drugs, and the study of microenvironments, stimuli, and responding cells are facilitated by the assay system.